Starita Lab

A significant barrier to the practice of precision medicine is our inability to interpret the genetic variation identified by genome sequencing. The Starita lab aims to develop the technology required to understand that variation, down to the single nucleotide level. We have applied Multiplexed Assays for Variant Effect to genes important for understanding cancer risk, such as BRCA1 and genes important for understanding drug metabolism, such as TPMT. Our current goal is to develop the next generation of Multiplexed Assays for Variant Effect with richer, more informative phenotypes and the ability to assess complex genotypes.