Before starting his PhD, Shawn worked as a genetic counselor at Brigham Women’s Hospital, where he experienced firsthand the difficulties that variants of uncertain significance (VUS) pose in the clinic. Unsatisfied with returning these VUS to patients, which cannot be used to guide medical management, Shawn decided to attack the problem by returning to graduate school where he works on: 1. Reclassifying VUS using high throughput functional data 2. Developing next generation saturation genome editing in iPSC differentiation systems 3. Rewriting the rules of using variant effect predictors for clinical variant interpretation Outside of the lab, Shawn can be found spending time outdoors riding his bike trying to find interesting birds.